Revealing the Alternatives to Apoquel for Dogs

Revealing the Alternatives to Apoquel for Dogs

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With increasing cases of allergies and itching in dogs, many pet owners have become familiar with Apoquel, a prescription medication designed to control the itching associated with allergic dermatitis and control atopic dermatitis in dogs. Although Apoquel has proven to be an effective solution, it’s not always the best choice for every dog. In this article, we’ll explore the question, “Is there an alternative to Apoquel for dogs?” to help you better understand your options.

What is Apoquel and Why Look for Alternatives?

Before diving into the alternatives, it’s vital to understand what Apoquel is and why some pet owners and vets might look for substitutes. Apoquel is a drug that inhibits the production of certain enzymes involved in the itching process, thus providing relief. However, it has some potential side effects, such as vomiting, diarrhea, and, in rare cases, more severe conditions like pneumonia and skin tumors.

Moreover, some dogs might have a pre-existing health condition that makes Apoquel a less suitable option, it cannot be used in dogs less than 12 months of age, and it cannot be used in dogs with serious infections. Finally, the cost of Apoquel can be prohibitive for some pet owners, prompting them to seek more affordable options. According to the FDA package insert, “New neoplastic conditions (benign and malignant) were observed in dogs treated with APOQUEL”, meaning it may be linked to cancer risk.

Apoquel Alternatives: Prescription Medications

Several prescription medications can be used as alternatives to Apoquel, and they fall into different categories.

  1. Corticosteroids: Prednisone, a type of corticosteroid, has been used for years to treat allergies in dogs. It’s effective but can have side effects if used long-term, such as increased thirst, urination, and potential weight gain.
  2. Cyclosporine (Atopica): Cyclosporine, sold under the brand name Atopica, is another alternative. It is an immunosuppressant medication that controls itching and inflammation. However, similar to Apoquel, it also has potential side effects, including vomiting and diarrhea.
  3. Cytopoint: Cytopoint is a newer drug that works differently from Apoquel. It’s a monoclonal antibody therapy that targets and neutralizes a key protein involved in triggering itch in dogs. It’s given by injection and each dose can last 4-8 weeks. It has minimal side effects, making it a popular choice among vets and pet owners.

Natural and Over-the-Counter Alternatives

If you’re looking for natural or over-the-counter alternatives to Apoquel, there are several options to consider.

  1. CBD Oil: Recent studies suggest that CBD oil might help manage inflammation and discomfort associated with skin conditions in dogs. However, more research is needed to confirm its efficacy and safety.
  2. Omega-3 Fatty Acids: These essential fatty acids, found in fish oils and flaxseed oils, can help reduce inflammation and promote healthy skin and fur. They are a safe, natural alternative, though they may not be as immediately effective as Apoquel.
  3. Topical Therapies: Various shampoos, creams, and sprays containing soothing ingredients like aloe vera, oatmeal, or hydrocortisone can provide immediate, localized relief for itchy skin.
  4. Probiotics: A healthy gut can improve overall health, including skin health. Probiotics can help balance the gut microbiome, potentially reducing allergy symptoms.
  5. Quercetin: Often referred to as nature’s Benadryl, quercetin is a plant-derived flavonoid with anti-inflammatory and antihistamine properties, helping to alleviate allergy symptoms.

Dietary Changes

Certain dietary changes may also help control your dog’s allergy symptoms. Hypoallergenic diets, which are free from common allergens like beef, chicken, wheat, and dairy, can sometimes help alleviate symptoms. Novel protein diets, featuring less common sources of protein like venison or duck, can also be beneficial.

Remember that dietary changes should be implemented gradually and under the supervision of your vet to avoid digestive upset and ensure nutritional needs are being met.

Holistic Therapies

Holistic therapies like acupuncture and herbal remedies are gaining traction as alternative treatments for allergies in dogs. While they may not work for every dog, some pet owners have reported positive results.

  1. Acupuncture: This ancient Chinese therapy is believed to restore balance in the body and can help alleviate itching and inflammation in some dogs.
  2. Herbal Remedies: Certain herbs, such as nettle and licorice root, have anti-inflammatory properties and can be used to manage allergy symptoms.


Is there an alternative to Apoquel for dogs? Absolutely. Both prescription and over-the-counter alternatives are available, along with natural remedies, dietary changes, and holistic therapies. The best alternative will depend on your dog’s specific needs, underlying health conditions, and the severity of their symptoms.

Before making any changes to your dog’s allergy treatment plan, it’s crucial to consult with your vet. They can provide advice based on their professional knowledge and understanding of your dog’s unique situation. With the right approach, your dog can enjoy a comfortable, itch-free life without needing Apoquel.

Remember, while seeking alternatives to Apoquel, the goal should not merely be to find a less expensive or natural solution but to find the most effective and safe option for your furry friend. You want your dog to live a happy, comfortable life, and that often means finding the best way to manage any allergy symptoms they may have.

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