Trazodone for Dogs: Dosage, Side Effects, and Alternatives – Relievet

Trazodone for Dogs: Dosage, Side Effects, and Alternatives

Nali Macklin - March 22nd 2020

Dosage Of Trazodone For Dogs Side Effects

You’ve desperately tried everything from Googling do-it-yourself training to spending hundreds of dollars on professional dog trainers, but nothing seems to help ease your dog’s fear & anxiety.

Whether it’s vet visits, loud noises (like thunderstorms & fireworks), or just leaving him alone for 10 minutes, your pooch becomes nothing less than a nervous wreck.

Finally, your vet suggests prescribing him Trazadone or other doggie downers (prescription anti anxiety medications).

“Wait, as in Trazadone for humans? Is that safe to give my dog?”

Let’s explore. 

What is Trazodone?

For humans, Trazodone is an antidepressant prescribed to treat anxiety, depression, and mood-related disorders. However, this drug is also commonly prescribed by veterinarians for dogs suffering from separation anxiety and other anxiety-related issues.

Trazadone works by increasing the serotonin levels in the dog’s brain when it’s unbalanced.

Serotonin is a neurotransmitter that regulates many of the body’s functions, including behavior. When your dog doesn’t get enough serotonin, it can result in behavioral issues such as fear, aggression, and anxiety.

Dosage of TrazOdone

Vets can prescribe Trazodone for dogs (and sometimes cats), but this drug is only FDA approved for humans.

This drug is commonly available in 50mg, 100mg, 150mg, and 300mg tablets. Your vet can determine the proper dosage for your dog. 

When trazodone is given to dogs for instant release or daily use, vets will prescribe anywhere from 3mg per pound per day, all the way up to 40mg per pound per day. 

When trazodone for dogs is used in combination with other drugs such as antidepressants, they will generally advise on a dose between 4mg per pound per day and 30mg per pound per day. 
  

Side effects of Trazodone 

This drug should not be given to dogs with hypersensitivity to Trazadone as it can cause an allergic reaction.

While side effects of Trazodone are uncommon, the following symptoms can occur: 

  • Ataxia
  • Diarrhea
  • Increased Aggression
  • Increased Anxiety
  • Lethargy
  • Priapism (prolonged erections)
  • Sedation
  • Vomiting

In some cases, your dog can develop a condition called “Serotonin Syndrome” - the most severe potential side effect of Trazodone and can be life-threatening.

Serotonin syndrome occurs when Trazadone is taken in high doses, taken with other medications, or has a poor reaction with certain foods.

Signs of serotonin syndrome may include rapid heart rate, difficulty breathing, dilated pupils, or tremors/shivering. If your dog is showing these symptoms, you should contact your vet immediately.
  

Dosage Of Trazodone For Dogs Side Effects

Cost of Trazodone 

Trazodone is available as generic and brand names (Desyrel and Leptro).

According to drug.com, the average cost for 50mg of Trazodone is $10 for seven tablets.
Prices will also vary depending on the pharmacy you visit.
 

How does Trazodone interact with other drugs?

As mentioned earlier, the most severe potential side effect of Trazadone is developing serotonin syndrome.

The following medications could increase the risk of developing this condition and should use extreme caution when combined with Trazadone 

Drug
Drug 
AmitrazAmitriptyline
AmphetaminesClarithromycin
ClomipramineDextromethorphan
ErythromycinFluconazole
ItraconazoleKetoconazole
MetoclopramideParoxetine
PhenelzineSelegiline
SertralineTelithromycin
Tramadol

Certain drugs such as Carbamazepine, Modafinil, Phenobarbital, Phenytoin, and Rifampicin can decrease the effect of Trazadone.   

Dosage Of Trazodone For Dogs Side Effects

Are There Any Alternatives to Trazodone?

If you’re looking for a natural alternative to Trazadone for your dog, CBD oil will be your best choice. Many people have turned to CBD oil for dogs the help with anxiety-related issues.

CBD oil calms and soothes anxiety naturally by interacting with your dog’s natural endocannabinoid system.

CBD oil also has other known benefits for pain management, heart health, seizures, cancer, and as a natural remedy for arthritis in dogs.

Some side effects of CBD oil include dry mouth, lowered blood pressure, drowsiness, but nothing has caused severe harm to pets as far as we know. However, there are still ongoing researches on the side effects of CBD oil.

Learn more about natural remedies for arthritis in dogs here.
     

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